mTORC1 - Wikipedia
mTORC1 ... mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein kinase complex that functions as a nutrient/energy/redox sensor …
Regulation and metabolic functions of mTORC1 and mTORC2
mTOR is part of two protein complexes, mTORC1 and mTORC2, that are evolutionarily conserved from yeast to human. mTORC1 is the direct target of the clinically important drug rapamycin, which …
The molecular basis of nutrient sensing and signalling by mTORC1 in ...
Aug 23, 2023 · Recent studies of the molecular architecture of mTORC1 shed new light on its physiological functions and on the consequences of their dysregulation in cancer, type 2 diabetes and...
mTORC1, the maestro of cell metabolism and growth
Translation regulation by mTORC1 signaling. mTORC1 promotes translation of terminal oligopyrimidine (TOP) mRNAs via LARP1 phosphorylation. mTORC1 also enhances cap-dependent translation …
What Is mTORC1 Signaling and Why Does It Matter?
mTORC1 signaling is a central regulatory system within every cell, interpreting various internal and external signals. This molecular complex, known as mechanistic Target of Rapamycin Complex 1, …
mTORC1 restricts TFE3 activity by auto-regulating its presence on ...
Oct 31, 2024 · In this study, we provide evidence for an essential role of mTORC1 kinase activity in balancing the cytosolic/lysosomal mTORC1 ratio, thereby uncovering an auto-regulatory mechanism …
mTOR Signaling | Cell Signaling Technology
4 days ago · The first, mTOR complex 1 (mTORC1), is composed of mTOR, Raptor, GβL, and DEPTOR and is inhibited by rapamycin. It is a master growth regulator that senses and integrates diverse …
Regulation and metabolic functions of mTORC1 and mTORC2
mTOR is part of two protein complexes, mTORC1 and mTORC2, that are evolutionarily conserved from yeast to human. mTORC1 is the direct target of the clinically important drug rapamycin, which …
mTORC1, the maestro of cell metabolism and growth - PubMed
Jan 7, 2025 · As a key conductor of the balance between anabolic and catabolic processes, mTOR complex 1 (mTORC1) orchestrates the symphonic regulation of glycolysis, nucleic acid and lipid …
Lysosomal acid lipase is essential in cholesterol-mediated mTORC1 ...
Feb 13, 2026 · Cholesterol, as a signaling molecule, plays a critical role in regulating the mTORC1 signaling pathway within cells. Lysosomal acid lipase (LAL) is re…