Semaglutide - ALZFORUM
Semaglutide is a synthetic, long-acting analog of glucagon-like peptide-1, used to treat diabetes and obesity. Ozempic TM is a once-per-week injection formulation, while Rybelsus TM is a daily pill.
Semaglutide Does Not Treat Alzheimer’s. Could It Prevent Dementia?
Semaglutide mildly shifted some CSF AD biomarkers, although the drug is not expected to reduce amyloid. Some scientists believe semaglutide could prevent AD or other dementias, if started earlier.
NT-0796 | ALZFORUM
Dec 17, 2025 · Background NT-0796 is an oral, brain-penetrant inhibitor of inflammasomes that contain NLRP3, aka nod-like receptor family pyrin domain-containing protein 3. Inflammasomes are …
Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its ...
Lee TS, Park EJ, Choi M, Oh HS, An Y, Kim T, Kim TH, Shin BS, Shin S. Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies …
The Discovery and Development of Liraglutide and Semaglutide
Knudsen LB, Lau J. The Discovery and Development of Liraglutide and Semaglutide. Front Endocrinol (Lausanne). 2019;10:155. Epub 2019 Apr 12 PubMed.
Semaglutide ameliorates cognition and glucose metabolism
Dec 1, 2023 · Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. Neuropharmacology. …
Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction ...
Rubin R. Could GLP-1 Receptor Agonists Like Semaglutide Treat Addiction, Alzheimer Disease, and Other Conditions?. JAMA. 2024 May 14;331 (18):1519-1521. PubMed.
Baseline Characteristics from Evoke and Evoke+: Two Phase 3 …
Scheltens P, Atri A, Feldman H, Hansson O, Knop F, Sano M, Dethlefsen C, Johannsen P, León T, Hansen CT, Cummings J. Baseline Characteristics from Evoke and Evoke+: Two Phase 3 …
Semaglutide as a possible therapy for healthy aging: Targeting the ...
Jan 8, 2025 · Ortiz GU, de Freitas EC. Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging. Ageing Res Rev. 2024 Dec;102:102582. Epub 2024 Nov 14 PubMed.
Exploring the Impact of Semaglutide on Cognitive Function and …
Boboc IK, Dumitrelea PD, Meca AD, Mititelu-Tartau L, Bogdan M. Exploring the Impact of Semaglutide on Cognitive Function and Anxiety-Related Behaviors in a Murine Model of Alzheimer's Disease.