CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and …

Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T cells that contributes to antigen recognition, immune cell maturation, and immune cell signaling.

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

CD8+ (cytotoxic) T cells, like CD4+ Helper T cells, are generated in the thymus and express the T-cell receptor. However, rather than the CD4 molecule, cytotoxic T cells express a dimeric co-receptor, …

Aug 24, 2023 · Mutations in alpha chain cause CD8 deficiency, with recurrent bacterial infections (J Clin Invest 2001;108:117) Accumulate in advanced atherosclerotic plaques (Hum Pathol 2008;39:1756)

Jul 29, 2025 · CD8+ T cells serve as the immune system’s targeted killers, specializing in identifying and eliminating infected or cancerous cells. These cells are often referred to as “cytotoxic T lymphocytes” …

Learn about cytotoxic T cells, also referred to as CD8+ T cells, including cell activation, differentiation, and function in adaptive immune response.

Aug 26, 2024 · While CD8 is widely recognized as a co-stimulatory molecule for conventional CD8 + αβ T cells, recent reports highlight its multifaceted role in both adaptive and innate immune responses. …

CD8 is a glycoprotein present on approximately one-third of T cells in lieu of CD4. Similar to CD4, it binds to a monomorphic region MHC, although it binds to class I rather than to class II antigens. CD8 …

CD8 is a co-receptor (with TCR, T-cell receptor) for MHC Class I; mostly found on cytotoxic T cells, but also on natural killer cells, cortical thymocytes, and a subset of myeloid dendritic cells.