A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.

Germline pathogenic variants in BRCA1/BRCA2 are associated with ovarian cancer, fallopian tube cancer, primary peritoneal cancer, male breast cancer, prostate cancer, pancreatic …

Hoja informativa sobre los genes BRCA1 y BRCA2, qué hacer si la prueba de una persona indica que tiene cambios en uno de estos genes y las consecuencias de las pruebas genéticas.

These gene mutations are associated with an often aggressive form of breast cancer as well as ovarian cancer. Identification of the BRCA1 gene mutation by NCI-supported scientists as a …

Gen que da origen a una proteína que repara el ADN dañado. Las mutaciones (cambios) en el gen BRCA1 aumentan mucho el riesgo de presentar cáncer de mama y cáncer de ovario.

[PubMed Abstract] Findlay GM, Daza RM, Martin B, et al. Accurate classification of BRCA1 variants with saturation genome editing. Nature 2018; 562 (7726):217-222. [PubMed Abstract] …

A gene that makes a protein that repairs damaged DNA. Mutations (changes) in the BRCA1 gene significantly increase the risk of developing breast and ovarian cancer.

Jan 31, 2025 · This surgery is often used to reduce the risk of ovarian and fallopian tube cancer in those who are at high risk for the disease because of inherited harmful changes in BRCA1, …

Jul 12, 2017 · The BRCA1 and BRCA2 genes code for proteins that are critical for cells to repair damaged DNA. Specific inherited mutations in these genes increase the risk of several cancer …

Feb 14, 2025 · However, PALB2 interacts with BRCA1/2 to maintain the integrity of the homologous recombination pathway. Therefore, tumors that lack PALB2 activity may respond …