The apoptosome is a protein complex assembled around the adapter protein Apaf-1 during mitochondria -mediated apoptosis, which is stimulated by cellular stress. [3]

Mar 21, 2007 · The apoptosome is a cytosolic signalling platform that integrates intracellular death signals.

The apoptosome is a platform that activates apical procaspases in response to intrinsic cell death signals. Biochemical and structural studies in the past two decades have extended our …

Many proapoptotic stimuli trigger cytochrome c release from mitochondria, promoting the formation of a complex between Apaf-1 and caspase-9 in a caspase-activating structure …

Glossary Apoptosome The apoptosome is a heptameric protein complex of the intrinsic apoptotic pathway, which drives the activation of pro-caspase-9, which in turn activates pro-caspase-3.

Normally, the many subunits of the apoptosome are separated and inactive, circulating harmlessly through the cell. When trouble occurs, they assemble into a star-shaped complex, which …

The apoptosome: a cell death signaling platform In the intrinsic death pathway, cytochrome c binds to Apaf-1 and triggers apoptosome assembly in the presence of dATP. This platform …

The formation of the apoptosome is a critical event in the intrinsic pathway of apoptosis, which is regulated by the balance of pro-apoptotic and anti-apoptotic proteins, particularly in the …

The apoptosome is one of the two known molecular machines in mammals that arbitrate death in cell fate decisions (the other is the DISC, the death-inducing signaling complex that …

A heptameric apoptotic protease activating factor 1 (Apaf-1)-cytochrome-c complex. The apoptosome recruits and activates caspases that cleave intracellular substrates and ultimately …