eLife2h
Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...
eLife3d
TET2 contributes to gluconeogenesis and pathology of type 2 diabetes
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ...
eLife2d
Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage
This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic ...
eLife6d
The promise and peril of comparing fluorescence lifetime in biology revealed by simulations
Fluorescence lifetime imaging microscopy (FLIM) excels over the widely used fluorescence intensity imaging by allowing the measurement of absolute signal levels, independent of sensor concentration.
eLife6d
Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, USA ...
eLife7d
Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
Penn Ovarian Cancer Research Center and Basser Center for BRCA, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States ...
eLife5d
Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice
This valuable study examines how different exercise training intensities affect intestinal barrier function and gut microbiota composition over a 6-week period in mice. The evidence supporting the ...
eLife5d
Neuronal Development: Rethinking sensorimotor circuits
New research shows that the neural circuit responsible for stabilising gaze can develop in the absence of motor neurons, contrary to a long-standing model in the field.
eLife7d
PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron
This important paper takes a novel approach to the problem of automatically reconstructing long-range axonal projections from stacks of images. The key innovation is to separate the identification of ...
eLife4d
Oxytocin salvages context-specific hyperaltruistic preference through moral framing
This study presents a valuable finding that altruistic tendency during moral decision-making is context-dependent (present in the gain domain but absent in the loss domain) and its absence in the loss ...
eLife6d
Computational method pinpoints how cause-and-effect relationships ebb and flow over time
A new computer model can more accurately assess how causal relationships in complex real-world systems vary over time.
eLife10d
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...