Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss a ...

The San Francisco 49ers entered Saturday's game with just four running backs, and they lost one of them in the third quarter.

49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports.

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The San Francisco 49ers added some running back depth to their roster ahead of their preseason opener vs. the Denver Broncos.

The 49ers are facing the Broncos in their first preseason game. Here are fiveplayers fans should keep their eyes on during ...

The 49ers scored a touchdown on their opening series of the preseason, then their defense crumbled by halftime against the ...

The Radcliff, Ky. native was a wide receiver coming out of North Hardin. LOUISVILLE, Ky. - As fans of the Louisville football program know at this point, the Cardinals have an embarrassment of riches ...

San Francisco 49ers running back Jordan James did not suit up for the 49ers joint practice with the Denver Broncos. The ...

Nearly 40 players are brand new to the 49ers’ roster and poised to make their debut in Saturday’s preseason opener against ...

San Francisco 49ers running back Isaac Guerendo (shoulder) is expected to miss a couple of weeks, according to Matt Maiocco ...

The San Francisco 49ers seem to be off to a rough start with two concerning training camp injuries revealed by Kyle Shanahan.