Republican senators introduce bills targeting nitazenes, synthetic opioids potentially deadlier than fentanyl. New legislation aims to detect, classify, and sanction the threat.

Marking what they called a “high water mark” in the effort to combat the region’s fentanyl crisis, state and local officials announced Wednesday that they had seized 50 million doses of the deadly synthetic drug in raids across Pennsylvania this year.

Two men traveling on Interstate 78 in the Lehigh Valley have been charged with carrying about 20,000 fentanyl pills, Northampton County’s district attorney says.

New developments have emerged in the case surrounding the tragic overdose death of Robert De Niro’s grandson, Leandro De Niro.

The Drug Enforcement Administration (DEA) is promoting an anti-drug ad campaign from a Trump-affiliated nonprofit—including one spot that links fentanyl-contaminated marijuana to overdose deaths and depicts a lit cannabis joint as part of the macabre PSA.

A Palmdale mother has been charged with murder after officials said her 2-year-old son died from ingesting fentanyl.

New London police say they found about 26 grams of crack cocaine, eight grams of fentanyl and seven grams of meth at a Truman Street residence Wednesday night.

Montgomery County deputies are investigating a possible case of fentanyl poisoning linked to a flyer handed out at a local library. Two employees at the R.B. Tullis Library in New Caney reported falling ill Tuesday afternoon after receiving a damp, pink-tinted flyer from a woman in the parking lot, according to Precinct 4 Constable Rowdy Hayden.

President Donald Trump says fentanyl will be the subject of the “first question” he asks when he meets with China's president in South Korea, the last stop of his three-country Asia tour.