Showrunner R. Scott Gemmill has confirmed that characters who played patients, and became dear to viewers across the season, will not return but that "for the most part" all of the doctors and nurses will return for season two, although "some people might be working different hours and different shifts".

Noah Wyle was already an executive producer on The Pitt, in addition to leading the series and writing a few episodes, but he'll wear another hat for season 2.