Get a prediction, pick and odds for the NFL Week 2 matchup between the San Francisco 49ers and the New Orleans Saints.

Left tackle Trent Williams, dealing with a knee issue, was limited in practice on Friday, ahead of the 49ers’ Week 2 clash with the Saints.

But it's Week 2, the 49ers are 1-0 and lots of their starters will be out this Sunday. I'm talking Purdy, Kittle, and possibly Ben Bartch and Jauan Jennings, too. They haven't practiced this week, either. Which means if Williams plays on his injured knee, the 49ers still could lose, and he might make the injury worse than it already is.

The 49ers enter Sunday’s game in New Orleans seeking to open a season with back-to-back road wins like in 2019, ’21 and ’23.

San Francisco 49ers quarterback Brock Purdy is a “long shot” to play against the Saints on Sunday in New Orleans, coach Kyle Shanahan said Wednesday, and could miss multiple weeks with an injury to his big toe. Purdy did not practice Wednesday.

Former Iowa State football QB Brock Purdy will be sidelined for multiple weeks due to a turf toe injury, the San Francisco 49ers announced Thursday.

Following the team’s 17-13 win over its NFC West rival, the Seattle Seahawks, the 49ers placed All-Pro tight end George Kittle on IR due to a hamstring injury. RB Christian McCaffrey is also dealing with his calf issues again this season. WR Jauan Jenning also left the Week 1 game with a shoulder injury, but he should be fine.