Some southern Illinois facilities will receive part of more than $69 million in health care grants.

For the first time since 2007, the Southern Illinois Salukis will host a nationally televised game in Carbondale.

The Indiana State Sycamore baseball team slipped by the Southern Illinois Salukis 9-7 in Missouri Valley Conference baseball action Friday night at Bob Warn Field. ISU was coming off a 9-8 victory in ...

Southern Illinois Republican lawmakers are criticizing the new $55.9 billion Illinois state budget approved during an ...

The No. 8 seed Southern Illinois Salukis will face the No. 9 seed Indiana State Sycamores in the first round of the 2025 Missouri Valley Conference Tournament on Thursday afternoon. These teams met in ...

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Carbondale freshman phenom Kai Manzano earned his place at the boys state tournament last weekend, finishing with a 3-2 ...

Discover cozy Southern Illinois cafés with great coffee, pastries, small-town charm, and road-trip-worthy vibes hiding beyond ...

State Senator Dale Fowler announced his resignation from the Illinois Senate following the 2026 legislative session, ...

WOODLAWN, Ill. (WLS) -- First there was the total solar eclipse in Illinois, and now there have been a series of earthquakes. Southern Illinois has seen an uptick in quakes recently. There have been ...

Republican U.S. Senate candidate Don Tracy heads to the November midterm election hoping to flip a senate seat from blue to ...