The strikes come less than a month after an ISIS gunman ambushed U.S. troops in Syria, killing three U.S. servicemembers—two Iowa National Guard soldiers and a civilian interpreter. The assault marked the first deadly attack on U.S. troops in Syria since the fall of President Bashar al-Assad.

They’re the first American airstrikes reported in Syria this year and the second wave of Operation Hawkeye Strike.

"These strikes are part of Operation Hawkeye Strike, which was launched and announced on Dec. 19, 2025, at the direction of President Trump, in direct response to the deadly ISIS attack on US and Syrian forces in Palmyra, Syria, on Dec. 13, 2025," CENTCOM said in a post on X.

US CENTCOM footage shows A-10 Warthogs and F-15s hammering ISIS targets in Syria during Operation Hawkeye Strike retaliation for Palmyra ambush; over 100 munitions hit 70+ sites with partners., US News,