Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Researchers have developed a revolutionary microscope that uses an incredibly powerful laser to make previously invisible ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

Key points of this article I have obtained a technical paper written by Mr. Kato, the designer of the Nikon Portable Microscope Model H, which was released in 1958. The article "Portable Microscope ...

Physicists have demonstrated a laser-based method that enables a cryogenic electron microscope to image small protein structures with greater detail than previously possible. The laser phase plate ...

You know when you are at the eye doctor getting an updated prescription, and suddenly the world snaps into sharper focus? Physicists at the University of California (UC), Berkeley, have now done ...

A continuous laser focused to a few microns, carrying 75 kilowatts of power, has been used to sharpen cryo-electron ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

A microscope born in post-war JapanThis time, I am introducing an old Olympus biological microscope, the UCE model 'Homare'.While the modern-day Olympus is known globally for its medical endoscopes, ...