In Sporting News' Week 10 picks against the spread, Philadelphia and San Francisco getting massive wins for their NFC playoff hopes while the Steelers keep up with the Ravens in the AFC North.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

NFL Week 10 picks, predictions for games this week, including Bills-Dolphins, Ravens-Vikings, Lions-Commanders, Steelers-Chargers, Eagles-Packers.

10 – New England Patriots (LW: 11) – The Pats are 7-2 and they have the NFL’s easiest remaining schedule. This weekend’s game against the Bucs will arguably be the toughest test they’ve faced thus far.

The Panthers proved against the Packers that they can be a playoff team – and Rico Dowdle has three games with 100 or more rushing yards in the last five weeks. The Saints allow 129.4 rushing yards per game, too. Carolina is 3-1 S/U at home this season.

On the positive side of the NFL betting trends spectrum, Tampa is 4-0 SU and 3-1 ATS as a favorite this year. It also has won and covered six straight regular-season games when laying 4 points or fewer. • New England quarterback Drake Maye has thrown multiple TD passes in four straight contests and seven of his last eight.

Going into the 2025 NFL season, there was a bit of caution surrounding the Los Angeles Rams. Sure, they made the playoffs last year, but it took an incredible r