Tubulin acts as a master regulator, preventing Tau and alpha-synuclein from forming toxic clumps in Alzheimer's and Parkinson's.

Scientists at Zhengzhou University and affiliated organizations synthesized and optimized a series of thienopyridine indole derivatives leading to the identification of compound [I] as the lead ...

Cell division, i.e., the process through which a parent cell divides into two daughter cells, is fundamental to the growth, repair, and reproduction of living organisms. During cell division, ...

Microtubule-targeting agents impact microtubule dynamics to induce mitotic arrest and tumor cell death. Tubulin is therefore a relevant target for the discovery of new agents acting as tumor ...

Kinesin proteins eat away at microtubules, shortening them and pulling chromosomes to opposite spindle poles during cell division in most organisms. However, fission yeast lacks these proteins, and ...

Mitotic cell division, when a cell splits into two identical daughter cells, involves lots of moving parts that must be properly organized for accurate segregation. The main players responsible for ...

An image of a large segment of a microtubule with a peeling tip. The colors highlight the different protofilaments that make up the tubule. The protofilaments are long biopolymers consisting of the ...