People with end stage ALS lose the ability to breathe, have limited mobility as muscles become paralyzed, and may no longer be able to speak. Amyotrophic lateral sclerosis (ALS) affects certain nerve ...

Signs and symptoms Progressive muscle weakness occurs in all cases of ALS, but this may not be the first indication of the condition. In the early stages, signs and symptoms may be barely noticeable.

A blood test that detects proteins unique to amyotrophic lateral sclerosis (ALS) can identify those with disease years before symptoms appear, new research suggests. "We had always assumed that ALS ...