Adeno-associated virus (AAV) mediates gene targeting in humans by providing exogenous DNA for allelic replacement through homologous recombination. In comparison to other methods of DNA delivery or ...

Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

In the hours after a heart attack, an intravenous dose of the bacterial protein streptokinase can break up blood clots and restore circulation. But it’s not ideal: Like other clot-busting drugs, ...

DNA/DNA double-stranded oligonucleotide is a new concept of oligonucleotide consisting of DNA-based antisense oligonucleotide and DNA-based complementary strand. When α-tocopherol is bound to ...

For decades, scientists have been intrigued by tiny viruses whose genetic material can be read both forward and backward. New research begins to explain this puzzling property. In 1971, ...

Generation of Microgram Quantities of sgRNA in Less Than One Hour CRISPR is an acronym for Clustered Regularly Interspaced Palindromic Repeats, which are genomic loci found in many bacteria and ...