The first antihistamine that the Food and Drug Administration approved was diphenhydramine. The compound was created in 1943, and the Parke-Davis pharmaceutical company brought it to market in 1946 ...
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Is Benadryl Risky?

A recent medical review argued that the risks of the antihistamine Benadryl outweigh its benefits, and highlighted significant hazards of long-term use. Newer antihistamines have fewer side effects ...