The Rams are favored by 4.5 points against the 49ers, marking their biggest underdog spread at Levi's Stadium since 2019. The Niners, though, have made the improbable seem routine this season.

The San Francisco 49ers lost another key defensive player for the season when rookie Mykel Williams went down with a knee ...

The Los Angeles Rams will do battle with NFC West division rival, the San Francisco 49ers in a game that could spark ...

The Sporting News is tracking live scoring updates and highlights for 49ers vs. Falcons on "Sunday Night Football." Follow ...

Christian McCaffrey caught a touchdown pass from Mac Jones, rushed for another score and the San Francisco 49ers got back on ...

Kyle Shanahan shed light on wide receiver Ricky Pearsall's knee injury that will hold him out of the team's Week 10 action.

George Kittle has just 75 yards in the three games that he has played since returning from an injury that sidelined him for ...

The 49ers will get some key players back this week led by defensive end Bryce Huff, who missed the past two games with a ...

The 49ers welcomed Special Olympics athletes for an unforgettable day of flag football, teamwork, and celebration bringing ...

Kyle Shanahan and Sean McVay have faced off 18 times leading their respective teams, with Shanahan currently holding an 11–7 ...

The San Francisco 49ers got the best of the Los Angeles Rams the last time these two teams met in Week 5. San Francisco upset ...