One of the biggest was only having star running back Christian McCaffrey for four games. At the beginning of the year, McCaffrey was dealing with Achilles issues. He then suffered a knee injury after making his return to the field.

The San Francisco 49ers hope that star running back Christian McCaffrey can return to form after missing most of last season with injuries.

The 49ers have so many players who need to step up this year. Most of all, Christian McCaffrey needs to be special.