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Ohio State vs Penn State prediction, odds, time, line

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· 8h

Ohio State vs. Penn State Prediction, Odds, Picks - November 1, 2025

The Buckeyes are double-digit, 20.5-point favorites.

· 1h · on MSN

How can Ohio State football beat Penn State? 3 keys as Buckeyes begin November stretch

· 16h · on MSN

Ohio State vs. Penn State prediction, pick, odds, spread: Lions looks to end skid against No. 1 Buckeyes

· 1h

Staff picks for Penn State vs. Ohio State in Week 10

This one may not be pretty, as our staff seems to be on the same page with the expected outcome this weekend.

· 14h

Live coverage of Penn State hockey at Ohio State Big Ten opener

· 19h

Trip to Ohio State a return home for Penn State’s quarterback

· 1d

Our Ohio State football experts make bold predictions for Penn State game

It was eye-catching for the Buckeyes to open as nearly three-touchdown favorites considering a decade has passed since they defeated the Nittany Lions by such a wide margin.

· 1d

How to watch Penn State football vs. Ohio State

· 1d

Five reasons for concern for Penn State against Ohio State

20hon MSN

Top-ranked Ohio State looks to continue rolling along when it hosts reeling Penn State

Penn State thought it had a win over Ohio State when Jim Knowles left to become the Nittany Lions defensive coordinator.

2hon MSN

Ohio State football will honor a coaching great during its game vs. Penn State: Buckeye Breakfast

COLUMBUS, Ohio — Urban Meyer will be at Ohio Stadium on Saturday for a multitude of reasons. The former Ohio State football coach will be on site for FOX to preview the Buckeyes’ game against Penn State. However, he’ll also be recognized for his accomplishments.

15h

Will Ohio State’s defense shut down Penn State’s offense? 🤔 Joel Klatt Show

Joel Klatt previewed the Big Noon Kickoff game between the Penn State Nittany Lions and the Ohio State Buckeyes. He explained why this matchup is going to be interesting between the Penn State DC Jim Knowles and Ohio State HC Ryan Day.

1don MSN

Behind Enemy Line: Talking to a Penn State expert about Ohio State vs. Penn State

Ohio State football hosts Penn State Saturday. We discussed the matchup to get an opposite sideline view with Kevin McGuire of Nittany Lions Wire.

7hon MSN

The Pros and Cons of Hiring Ohio State's Brian Hartline at Penn State

Hartline is a lifetime Buckeye and sharp offensive mind being targeted by multiple programs as a potential head coach.

Ohio State-Penn State preview: Can Buckeyes’ run game break out vs. Jim Knowles?

Ohio State-Penn State is not the marquee matchup many expected. Will Knowles and the Nittany Lions have any surprises in Columbus?

13mon MSN

Ohio State vs. Penn State stars report: How big is the Buckeyes’ talent gap in the starting 22?

Ohio State is the No. 1 team in the country and enters the matchup against Penn State at 7-0. That part isn’t surprising. Penn State entering at 3-4, having already fired coach James Franklin, is about as surprising as anything else in college football this year.