Israel and Iran have opened a new chapter in their long history of conflict when Israel launched a major attack with strikes early Friday on Tehran.

Regime change in Iran could be a result of Israel's military attacks on the country, Israeli Prime Minister Benjamin Netanyahu told Fox News on Sunday, saying Israel would do whatever is necessary to remove the "existential threat" posed by Tehran.

Iranians close to military sites "should immediately leave these areas and not return until further notice," the Israeli military said on Sunday.

Experts have said it is likely that Iran is using the bulk of its ballistic missiles to “distract and saturate” air defences to create an opening for more advanced weapons. That missile appears to be the Shahed Haj Qassem, which was fired at Israel for the first time at the weekend.

The Iron Dome is designed to protect Israeli citizens by launching guided missiles to intercept incoming rockets and other short-range threats in mid-air.

The "America First" president praised his foreign policy record on Sunday while urging a deal between Iran and Israel amid escalating strikes.

Israel has launched hundreds of air strikes since the early hours of June 13th. Iran has responded with salvoes of ballistic missiles and drones, although only a handful have penetrated Israel’s defence systems.

Health officials say at least eight Palestinians were killed and dozens more wounded in the latest shooting near Israeli- and U.S.-supported food distribution points in Gaza.